Production of NAADP and its role in Ca mobilization associated with lysosomes in coronary arterial myocytes
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منابع مشابه
Production of NAADP and its role in Ca2+ mobilization associated with lysosomes in coronary arterial myocytes.
The present study was designed to determine the production of nicotinic acid adenine dinucleotide phosphate (NAADP) and its role associated with lysosomes in mediating endothelin-1 (ET-1)-induced vasoconstriction in coronary arteries. HPLC assay showed that NAADP was produced in coronary arterial smooth muscle cells (CASMCs) via endogenous ADP-ribosyl cyclase. Fluorescence microscopic analysis ...
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Activation of the death receptor Fas has been implicated in the development of vascular injury or disease, but most studies have focused on its role in the regulation of cell apoptosis and growth. The present study was designed to examine the early response of coronary artery to Fas activation by its ligand, FasL. The hypothesis being tested is that CD38 signaling pathway mediates FasL-induced ...
متن کاملTRP-ML1 Functions as a Lysosomal NAADP-Sensitive Ca Release Channel in Coronary Arterial Myocytes
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent intracellular Ca signalling second messenger, but the mechanism of NAADP-induced Ca release is still poorly understood. The present study tested the hypothesis that NAADP induces Ca release from the lysosomal store via a TRP-ML1 (transient receptor potential-mucolipin 1)-mediated Ca release channel in coronary arterial myocytes (...
متن کاملTRP-ML1 functions as a lysosomal NAADP-sensitive Ca2+ release channel in coronary arterial myocytes
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent intracellular Ca(2+) signalling second messenger, but the mechanism of NAADP-induced Ca(2+) release is still poorly understood. The present study tested the hypothesis that NAADP induces Ca(2+) release from the lysosomal store via a TRP-ML1 (transient receptor potential-mucolipin 1)-mediated Ca(2+) release channel in coronary art...
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